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GluteGuard is a clinically supported enzyme supplement that helps to minimise the occurrence of symptoms caused by accidental gluten ingestion in those with coeliac disease and medically diagnosed gluten sensitivities [1]

Inadvertent Gluten Ingestion

Despite a strict gluten-free diet, patients with coeliac disease and other gluten-related disorders continue to suffer from symptoms caused by accidental gluten ingestion when food preparation is out of their control or due to poor product labelling. The challenges and anxiety of following a strict gluten-free diet can create social complications, impact well-being, and reduce quality of life, especially for those newly diagnosed.

Occurrence and Impact of Ongoing Gluten Exposure in Coeliac Patients

Average inadvertent exposure to gluten for coeliac individuals on a strict gluten-free diet was estimated to be ~150-400 mg per day [2].

As little as 10mg of gluten was shown able to trigger symptoms in some individuals and the ongoing consumption of 50mg of gluten was enough to cause intestinal damage in coeliac individuals [3]

Ongoing intestinal damage was identified in 56% of coeliac patients at significant levels. This is believed to be associated with lack of adherence to a gluten-free diet often due to inadvertent gluten ingestion [4]

Health-related quality of life of Australian patients reporting persisting symptoms of CD despite strict adherence to a gluten-free diet is sub-optimal, with concerning low scores for emotional quality [5]

How does GluteGuard help?

When gluten is consumed, several peptides containing toxic or immunogenic motifs are left undigested by the body’s gastrointestinal proteases. These peptides interact with the intestinal lining resulting in symptoms and the autoimmune response that leads to intestinal damage in coeliac disease.

GluteGuard’s unique, patented action uses caricain, a natural, plant-derived enzyme, extracted from the papaya fruit skin (Carica papaya).

When GluteGuard is taken immediately before a meal that could possibly be contaminated with gluten, GluteGuard’s enteric coating ensures quick delivery to the duodenum where the natural enzymes are released. GluteGuard’s potent enzymes are able to break down the the toxic and immunogenic gluten peptides before they can interact with the intestinal lining. Once broken down into harmless fragments, these peptides are digested normally without causing symptoms or immune activation.

In this way, GluteGuard provides peace of mind and protection against accidental gluten ingestion to support health and well-being. GluteGuard enhances the gluten-free diet, it is not intended to replace it.

Clinically Proven in Coeliac Patients [6]

GluteGuard has been studied in randomized, double-blinded, placebo-controlled clinical trials involving patients with coeliac disease. The most recent trial recorded symptoms daily in 20 individuals diagnosed with coeliac disease while being challenged with one gram of gluten daily for 42 days. Serology and small bowel histology was monitored at the start and end of the study.

GluteGuard was able to minimize the effect of daily gluten challenge in symptoms and wellbeing:

When compared with the placebo, GluteGuard was able to significantly protect coeliac patients from the symptoms caused by the daily gluten challenge with 1g daily (p<0.01)

Patients on GluteGuard reported a higher feeling of well-being than the placebo patients (p<0.01)

67% of the placebo group were unable to complete the gluten challenge due to the symptoms experienced, most of them abandoning the challenge by day 14

Despite concluding the 42-day gluten challenge, there was no significant exacerbation of intestinal damage in patients using GluteGuard

*This study was designed to resemble a scenario where gluten is consumed inadvertently on a regular basis.

GluteGuard Brochure

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Product Information

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Clinical Trials in Coeliac Disease

CORNELL ET. AL. (2016)- THE EFFECT OF ENZYME SUPPLEMENTATION ON SYMPTOMS AND DUODENAL HISTOLOGY IN COELIAC PATIENTS

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Clinical Trials in Dermatitis Herpetiformis

ZEBROWSKA ET. AL (2014) – THE EFFECT OF ENZYME THERAPY ON SKIN SYMPTOMS AND IMMUNE RESPONSES IN PATIENTS WITH DERMATITIS HERPETIFORMIS

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References

  1. GluteGuard Product Information
  2. J. Syage et. al. (2018) Determination of gluten consumption in celiac disease patients on a gluten-free diet. Am J Clin Nutr 2018;107:201–207
  3.  Fasano, A et al (2007), ‘A prospective double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease’, Am J Clin Nutr, 85, pp.160-166.
  4. Ciacci et al. 2002- Long-Term Follow-Up of Celiac Adults on Gluten-Free Diet: Prevalence and Correlates of Intestinal Damage. Digestion; 66(3):178-85.
  5. Harnett  J. et al: “Quality of life in people with ongoing symptoms of coeliac disease despite adherence to a strict gluten–free diet”. Nature Research (2020) 10:1144
  6. Cornell et. al. (2016) – The Effect of Enzyme Supplementation on Symptoms and Duodenal Histology in Coeliac Patients